Human pIgR Protein, His Tag

Source : 

Human pIgR, His Tag (PIR-H5222) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - Arg 638 (Accession # AAI10495.1).

 

Molecule : pIgR

 

Synonyms : PIGR,Poly-Ig receptor

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAI10495.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 68.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 68.7 kDa. The protein migrates as 85-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

 

References :

(1) Krajci P., et al., 1991, Hum. Genet. 87:642-648.
(2) Eiffert H., et al., 1984, Hoppe-Seyler's Z. Physiol. Chem. 365:1489-1495.
(3) Hughes G.J., et al., 1997, FEBS Lett. 410:443-446.
(4) Hamburger A.E., et al., 2004, Structure 12:1925-1935.