Human PDGF R alpha / PDGFRA Protein, His Tag

Source : 

Human PDGF R alpha, His Tag (PDA-H52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Ala 528 (Accession # P16234-1).

 

Molecule : PDGF R alpha

 

Synonyms : PDGFRA,CD140A,PDGFR2,RHEPDGFRA,MGC74795

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_006197.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 58.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.4 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

PDGFRA(platelet-derived growth factor receptor A), also termed PDGFRα(platelet-derived growth factor receptor α), is a receptor located on the surface of a wide range of cell types. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the development of certain tissues and organs during embryogenesis and for the maintenance of these tissues and organs, particularly hematologic tissues, throughout life. Mutations in the gene which codes for PDGFRA, are associated with an array of clinically significant neoplasms.

 

References :

(1) Matsui T, et al. 1989. Proc Natl Acad Sci U S A. 86(21):8314-8.
(2) Kelly JD, et al. 1991. J Biol Chem. 266(14):8987-92.
(3) Koschmann C, et al. 2016. Oncotarget. 7(40):65696-65706.