Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag

Source : 

Human Osteoprotegerin, Fc Tag (TNB-H5259) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Leu 401 (Accession # NP_002537).

 

Molecule : Osteoprotegerin

 

Synonyms : TNFRSF11B,OCIF,OPG,Osteoprotegerin

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_002537

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 70.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 70.2 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

 

References :

(1) Tsuda E., et al, 1997, Biochem. Biophys. Res. Commun. 234:137-142.
(2) Emery J.G., et al., 1998, J. Biol. Chem. 273:14363-14367.
(3) Luan X., et al., 2012, J. Immunol. 189:245-252.