Human Osteoactivin / GPNMB Protein, His Tag

Source : 

Human Osteoactivin, His Tag (GPB-H5229) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Pro 486 (Accession # AAH32783).

 

Molecule : Osteoactivin

 

Synonyms : GPNMB,HGFIN,NMB,Osteoactivin

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH32783

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 53.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 53.4 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

 

References :

(1) Weterman MA., et al., 1995, International Journal of Cancer 60 (1): 73–81.
(2) Abdelmagid, SM., et al., 2008, Exp Cell Res 314 (13): 2334–51.
(3) Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1): 26–37.