Human NRG1 Beta 1 Protein, Fc Tag

Source : 

Human NRG1 Beta 1, Fc Tag (NR1-H5268) is expressed from human 293 cells (HEK293). It contains AA Ser 2 - Lys 246 (Accession # Q02297-6).

 

Molecule : NRG1 Beta 1

 

Synonyms : NRG1 Beta 1,HRG1 beta 1,Neuregulin-1 beta 1,Neuregulin1 beta 1,NRG1,ARIA,GGF,HGL,HRGA,NDF,SMDF

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_039250.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 53.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 53.2 kDa. The protein migrates as 65-80 kDa and 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

 

References :

(1) Britsch S. Adv Anat Embryol Cell Biol. 2007. 190:1-65.
(2) Talmage DA. Novartis Found Symp. 2008. 289:74-84.
(3) Orr-Urtreger A, et al. Proc Natl Acad Sci U S A. 1993. 90(5):1867-71.