Human Noggin protein expressed in mammalian cells
Proteins and Peptides
- 貨號 Cat. No.
- PE-1245-5
- 規格 Size
- 5 µg
- 品牌 Brand
- Biosensis
- Application 應用
- CC, Cell Culture
- Host
- Human - A DNA sequence encoding human Noggin protein (containing the signal peptide sequence and the mature human noggin sequence) was expressed in modified human 293 cells.
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Nog;
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(Antibody only) :
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Clone_Name
(AB only, monoclonals) :
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=902
Description (Long Description) :
Noggin is a glycoprotein predominantly expressed by the dorsal mesoderm during embryogenesis and is secreted as a covalently linked homodimer. Noggin is essential for cartilage morphogenesis and joint formation. It is an inhibitor of bone morphogenic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Defects in Noggin are a cause of symphalangism proximal syndrome (SYM1), of multiple synostoses syndrome 1 (SYNS1), of the tarsal-carpal coalition syndrome (TCC), of stapes ankylosis with broad thumb and toes, and of brachydactyly type B2 (BDB2).
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Format (Form) :
The Noggin product consists of 5-25% carbohydrate by weight.
Immunogen (Antigen) :
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