Human NKp30 / NCR3 / CD337 Protein, His Tag

Source : 

Human NKp30, His Tag (NC3-H5228) is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Gly 135 (Accession # AAH52582).

 

Molecule : NKp30

 

Synonyms : NCR3,CD337,NKp30,1C7,LY117,MALS

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH52582

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 13.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.7 kDa. The protein migrates as 21-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Natural cytotoxicity triggering receptor 3 (NCR3) is also known as Activating natural killer receptor p30, Natural killer cell p30-related protein (NK-p30), CD antigen CD337, 1C7, LY117. NCR3 /CD337 /NKp30 belongs to the natural cytotoxicity receptor (NCR) family. NCR3 /NKp30 contains one Ig-like (immunoglobulin-like) domain. NCR3 /NKp30 is selectively expressed by all resting and activated NK cells and weakly expressed in spleen. NCR3 is homodimer in the unliganted form. NCR3 interacts with CD3Z. NCR3 interacts with and is activated by binding to NCR3LG1 or BAG6. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

 

References :

(1) Pende D., et al., 1999, J. Exp. Med. 190:1505-1516.
(2) Vitale M., et al., 2005, Blood 106:566-571.
(3) Simhadri V.R., et al., 2008, PLoS ONE 3:E3377-E3377.