Human NKG2D / CD314 Protein, His Tag

Source : 

Human NKG2D, His Tag (NKD-H5245) is expressed from human 293 cells (HEK293). It contains AA Ile 73 - Val 216 (Accession # P26718-1).

 

Molecule : NKG2D

 

Synonyms : NKG2D,CD314,KLRK1,NK cell receptor D

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_031386.2 (T72A)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 18.5 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.5 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.

 

References :

(1) Li P, et al. 2001. Nat Immunol. 2(5):443-51.
(2) Brown MG, et al. 1997. Genomics. 42(1):16-25.
(3) González S1, et al. Trends Immunol. 2008. 29(8):397-403.