Human NKG2A&CD94 Protein, Mouse IgG2a Fc Tag

Source : 

Human NKG2A&CD94, Mouse IgG2a Fc Tag (NC4-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 113 - Leu 233 (NKG2A) & Asp 57 - Ile 179 (CD94) (Accession # P26715-1 (NKG2A) & Q13241-1 (CD94)).

 

Molecule : NKG2A & CD94

 

Synonyms : NKG2A & CD94

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002250.1 (NKG2A) & N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 55.5 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 55.5 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5

 

Description :

CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

 

References :

(1) Petrie EJ. J Exp Med. 2008. 205(3):725-35.
(2) Kaiser BK. Proc Natl Acad Sci U S A. 2008. 105(18):6696-701.
(3) Sun C, et al. Oncoimmunology. 2016. 6(1):e1264562.