Human Nerve Growth Factor Receptor-Fc Chimera (209 amino acids) expressed in mammalian cells
Proteins and Peptides
- 貨號 Cat. No.
- PE-1237-25
- 規格 Size
- 25 µg
- 品牌 Brand
- Biosensis
- Application 應用
- CC, Cell Culture
Description
ZZZZ_Status (Active, Disc) : Discontinued
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; p75NTR; CD271;
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Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=909
Description (Long Description) :
Nerve growth factor (NGF) receptor, also known as p75NTR, is a low affinity NGF receptor. It binds with equal affinity neurotrophins such as beta NGF, BDNF, NT-3 and NT-4. NGF receptors mediate signaling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. These receptors are also thought to play a role in neurogenerative diseases such as Alzheimers disease. The NGF receptor is a type I transmembrane glycoprotein (399 aa) consisting of a signal peptide (28 aa), an extracellular domain (222 aa) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 aa) and a cytoplasmic domain (155 aa).
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Format (Form) :
The NGF Receptor-Fc chimera consists of 25-45% carbohydrate by weight.
Immunogen (Antigen) :
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