Human Nectin-4 Protein, Fc Tag

Source : 

Human Nectin-4, Fc Tag (NE4-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 32 - Ser 349 (Accession # Q96NY8-1).

 

Molecule : Nectin-4

 

Synonyms : NECTIN4,LNIR, PRR4, PVRL4

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_112178.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 60.5 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.5 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

 

References :

(1) Reymond N., et al. 2001, J Biol Chem., 276(46), 43205-15.
(2) Ma J., et al. 2016, Onco Targets Ther., 9, 183-90.
(3) Nabih ES., et al. 2014, Biomarkers., 19(6), 498-504.