Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag

Source : 

Human Nectin-2, Mouse IgG2a Fc Tag (CD2-H5257) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Leu 360 (Accession # Q92692-2).

 

Molecule : Nectin-2

 

Synonyms : CD112,Nectin-2,PVRL2

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_002847.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 62.4 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 62.4 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

 

References :

(1) Martinez W.M., et al., 2001, J. Virol. 75:11185-11195.
(2) Yu X., et al., 2009, Nat. Immunol. 10:48-57.