Human Mucin-1 / MUC-1 Protein, Llama IgG2b Fc Tag, low endotoxin

Source : 

Human Mucin-1, Llama IgG2b Fc Tag, low endotoxin (MU1-H5255) is expressed from human 293 cells (HEK293). It contains AA Ser 33 - Gly 167 (Accession # AAI20976).

 

Molecule : Mucin-1

 

Synonyms : Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001018016.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 42.4 kDa

 

Characteristics :

This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 42.4 kDa. The protein migrates as 50-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.01 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.

 

References :

(1) Gendler SJ., et al., 1990, J. Biol. Chem. 265 (25): 15286-93.
(2) Hollingsworth MA., et al., 2004, Nat. Rev. Cancer 4 (1): 45-60.
(3) Moncada DM., et al., 2003, Trends Parasitol 19 (7): 305-311.
(4) Singh PK., et al., 2006, Trends Cell Biol 16 (9): 467-476.
(5) Lindén SK., et al., 2009, PLoS Pathog. 5 (10): e1000617.