Human Mucin-1 / MUC-1 (890-1158) Protein, His Tag

Source : 

Human Mucin-1 (890-1158), His Tag (MU1-H52H9) is expressed from human 293 cells (HEK293). It contains AA Ser 890 - Gly 1158 (Accession # P15941-1).

 

Molecule : Mucin-1

 

Synonyms : Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 21.3 kDa (partial α chain) & 8.4 kDa (partial β chain)

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 21.5 k

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.

 

References :

(1) Gendler SJ., et al., 1990, J. Biol. Chem. 265 (25): 15286-93.
(2) Hollingsworth MA., et al., 2004, Nat. Rev. Cancer 4 (1): 45-60.
(3) Moncada DM., et al., 2003, Trends Parasitol 19 (7): 305-311.
(4) Singh PK., et al., 2006, Trends Cell Biol 16 (9): 467-476.
(5) Lindén SK., et al., 2009, PLoS Pathog. 5 (10): e1000617.