Human MUC-17 Protein, His Tag

Source : 

Human MUC-17, His Tag (MU7-H52H3) is expressed from human 293 cells (HEK293). It contains AA Arg 4131 - Leu 4390 (Accession # Q685J3-1).

 

Molecule : MUC-17

 

Synonyms : Mucin-17,MUC-17,MUC17,MUC-3,MUC3

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 31.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. This protein was cleaved within the SEA domain between 4243 Gly and 4244 Ser, and was cleaved into N and C-terminal fragment with calculated MW of 12.6 kDa and 18.6 kDa respectively. The protein

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

 

References :

(1) James R Gum Jr, et al. Biochem Biophys Res Commun. 2002. 291(3):466-75.
(2) Emily K Malmberg, et al. Biochem J. 2008. 410(2):283-9.