Human MICA Protein, Fc Tag (MALS verified)

Source : 

Human MICA, Fc Tag (MALS verified) (MIA-H5253) is expressed from human 293 cells (HEK293). It contains AA Glu 24- Gln 308 (Accession # AAH16929.1).

 

Molecule : MICA

 

Synonyms : MIC-A

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH16929.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 59.3 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 59.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.

 

References :

(1) Groh V., et al., 1998, Science 279:1737-1740.
(2) Bauer S., et al., 1999, Science 285:727-729.
(3) Steinle A., et al., 2001, Immunogenetics 53:279-287.