Human MBL Protein, His Tag

Source : 

Human MBL, His Tag (MBL-H5220) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Ile 248 (Accession # P11226-1).

 

Molecule : MBL

 

Synonyms : MBL,MBL2,MBP1,MBP-C,Collectin-1,COLEC1,HSMBPC,MBL2D,MBPD

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH96179

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 25.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.9 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Mannose-binding lectin (MBL) is also known as mannose-binding protein, mannan-binding protein (MBP), Mannose-binding protein C, Collectin-1 (COLEC1), MBL2, which belongs to the class of collectins in the C-type lectin superfamily. MBL contains one C-type lectin domain and one collagen-like domain. MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each. MBL is calcium-dependent lectin involved in innate immune defense. MBL binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. MBL binds to late apoptotic cells. MBL may bind DNA.

 

References :

(1) Nauta A.J., et al., 2003, Eur. J. Immunol. 33:2853-2863.
(2) Hirano M., et al., 2005, J. Immunol. 175:3177-3185.