Human Mature PCSK9 (153-692) Protein, His Tag

Source : 

Human Mature PCSK9 (153-692), His Tag (PC9-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 153 - Gln 692 (Accession # Q8NBP7-1).

 

Molecule : PCSK9

 

Synonyms : PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAI66619.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 58.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.1 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 10 mM HCl, pH2.4

 

Description :

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

 

References :

(1) Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3): 928–33.
(2) Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
(3) Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8): 1454–9.