Human M-CSF / CSF-1 Protein, His Tag

Source : 

Human M-CSF, His Tag (MCF-H5247) is expressed from human 293 cells (HEK293). It contains AA Glu 33 - Arg 255 (Accession # P09603-1).

 

Molecule : M-CSF

 

Synonyms : M-CSF,CSF-1,Lanimostim

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : AAH21117.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 26.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 26.0 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. Macrophage colony-stimulating factor has been shown to interact with PIK3R2. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.

 

References :

(1)Sapi E., 2004, Exp. Biol. Med., 229 (1): 1-11.
(2)Jang Mei-Huei, 2006, The Journal of Immunology, 177 (6): 4055-4063.
(3)Cao, Qi, 2014, Kidney International, 85 (4): 794-806.