Human LYPD3 / C4.4A Protein, His Tag

Source : 

Human LYPD3, His Tag (LY3-H52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 31 - His 286 (Accession # AAH39167).

 

Molecule : LYPD3

 

Synonyms : LYPD3,MIG-C4,C4.4A

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH39167

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 28.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.7 kDa. The protein migrates as 45-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Ly6/PLAUR domain-containing protein 3 (LYPD3) is also known as MIG-C4 ,C4.4A, GPI-anchored metastasis-associated protein C4.4A homolog and Matrigel-induced gene C4 protein,which is a cell membrane protein containing two UPAR/Ly6 domains. LYPD3 is expressed in placenta, skin and urothelium. LYPD3 is found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. LYPD3 play a role in supporting cell migration and it is not only probably involved in urothelial cell-matrix interactions, but also in tumor progression.

 

References :

(1) Hansen L.V., et al., 2004, Biochem. Eng. J. 380:845-857.
(2) Fletcher G.C., et al., 2003, Br. J. Cancer 88:579-585.
(3) Oshiro R., et al., 2012, Cancer Sci. 103:1155-1164.