Human LTBR / TNFRSF3 Protein, Fc Tag

Source : 

Human LTBR, Fc Tag (LTR-H5251) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Met 227 (Accession # P36941-1).

 

Molecule : LTBR

 

Synonyms : LTBR,D12S370,TNFCR,TNFR3,TNFRSF3,TNFRIII

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002333

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48.4 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.4 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.

 

References :

(1) Rooney I.A., et al., 2000, J. Biol. Chem. 275:14307-14315.
(2) Nakano H., et al., 1996, J. Biol. Chem. 271:14661-14664.
(3) Krajewska M., et al., 1998, Am. J. Pathol. 152:1549-1561.