Human LSECtin / CLEC4G Protein, Fc Tag

Source : 

Human LSECtin, Fc Tag (CLG-H5250) is expressed from human 293 cells (HEK293). It contains AA Lys 55 - Cys 293 (Accession # Q6UXB4-1).

 

Molecule : LSECtin

 

Synonyms : CLEC4G,LSECtin

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_940894.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 52.1 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 52.1 kDa. The protein migrates as 58-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

C-type lectin superfamily 4, member G (CLEC4G) is also known as liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), which is a member of subgroup II of the C-type (Ca2+-dependent) lectin superfamily. CLEC4G / LSECtin binds to mannose, GlcNAc, and fucose in a Ca2+-dependent manner. In addition, CLEC4G / LSECtin has the ability to bind to surface glycoproteins of enveloped viruses. In particular, interaction of LSECtin with the surface glycoproteins of severe acute respiratory syndrome (SARS) coronavirus and Ebola virus has been described, and LSECtin-mediated infection of cells by Ebola virus has been demonstrated.

 

References :

(1) Liu W., et al., 2004, J Biol Chem. 279(18):18748-58.
(2) Powlesland AS., et al., 2008, J Biol Chem. 283(1):593-602.