Human LRRC32 / GARP / Garpin Protein, Fc Tag

Source : 

Human LRRC32, Fc Tag (LR2-H5256) is expressed from human 293 cells (HEK293). It contains AA His 20 - Asn 627 (Accession # Q14392-1).

 

Molecule : LRRC32

 

Synonyms : GARP,Garpin,D11S833E

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_005503.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 92.4 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.4 kDa. The protein migrates as 105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.

 

References :

(1) Battaglia, M., et al., 2009, Eur. J. Immunol. 39(12): 3296-3300.
(2) Wang, R. et al. 2008, PloS ONE 3(7): e2705.
(3) Probst-Kepper, M. et al. 2009, J. Cell. Mol. Med. 13(9B): 3343-3357.