Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag

Source : 

Human LRP-6 (20-630), Mouse IgG2a Fc Tag (LR6-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 630 (Accession # O75581-1 ).

 

Molecule : LRP-6

 

Synonyms : LRP-6,LRP6

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_002327.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 95.8 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 95.8 kDa. The protein migrates as 55 kDa and 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

 

References :

(1) Williams BO, et al. 2009. J Bone Miner Res. 24(2):171-8.
(2) Li X, et al. 2005. J Biol Chem. 280(20):19883-7.
(3) Zeng X, et al. 2005. Nature. 438(7069):873-7.