Human LRP-5 Protein, Mouse IgG2a Fc Tag

Source : 

Human LRP-5, Mouse IgG2a Fc Tag (LR5-H5254) is expressed from human 293 cells (HEK293). It contains AA Glu 644 - Gln 1263 (Accession # O75197-1 ).

 

Molecule : LRP-5

 

Synonyms : LRP5,LRP-5,LRP-7,LRP7,LR3

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_002326.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 96.6 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 96.6 kDa. The protein migrates as 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

 

References :

(1) Li X, et al. 2005. J Biol Chem. 280(20):19883-7.
(2) Hey PJ, et al. 1998. Gene. 216(1):103-11.
(3) Williams BO, et al. 2009. J Bone Miner Res. 24(2):171-8.