Human LILRB5 / CD85c / LIR-8 Protein, His Tag

Source : 

Human LILRB5, His Tag (CDC-H5220) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Gly 458 (Accession # NP_006831).

 

Molecule : LILRB5

 

Synonyms : LILRB5,CD85c,LIR-8

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_006831

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 49.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.2 kDa. The protein migrates as 66-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Leukocyte immunoglobulin-like receptor subfamily B member 5 (LILRB5), also known as CD85c and LIR-8, belongs to the leukocyte immunoglobulin-like receptor (LIR) family of transmembrane glycoproteins that negatively regulate immune cell activation. Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response.

 

References :

(1)Liu T., et al., 2006, J. Proteome Res., 4 (6): 2070-2080.
(2)Thomas, R. et al., 2010, Clin. Rev. Allergy Immunol., 38: 159-162.
(3)Zheng, J. et al., 2012, Nature, 485: 656-660.