Human LILRB3 / CD85a / ILT5 Protein, Fc Tag

Source : 

Human LILRB3, Fc Tag (CDA-H5250) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Glu 443 (Accession # AAB68668 (P288R)).

 

Molecule : LILRB3

 

Synonyms : LILRB3,CD85a,ILT5

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAB68668 (P288R)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 72.8 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.8 kDa. As a result of glycosylation, the protein migrates as 90-115 kDa under reducing (R) condition, and 150 kDa under non-reducing (NR) condition (SDS-PAGE

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Leukocyte immunoglobulin-like receptor subfamily B member 3 is also known as LILRB3,ILT-5 or CD85a. LILRB3 plays an role as receptor for class I MHC antigens, which activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. LILRB3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through association with an activating adaptor molecule, FcRγ.

 

References :

(1) Bashirova AA., et al., 2014, Immunogenetics.66(1):1-8.
(2) Huang J., et al., 2010, J Virol. 84(18):9463-9471.
(3) Pfistershammer K., et al., 2009, Blood. 114(11):2323-2332.