Human LILRB2 / CD85d / ILT4 Protein, His Tag

Source : 

Human LILRB2, His Tag (LI2-H5220) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Val 461 (Accession # AAH36827).

 

Molecule : LILRB2

 

Synonyms : LILRB2,ILT4,LIR2,MIR10,CD85d

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAH36827

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.6 kDa. The protein migrates as 58-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

 

References :

(1) Borges L., et al., 1997, J. Immunol. 159:5192-5196.
(2) Fanger N.A., et al., 1998, Eur. J. Immunol. 28:3423-3434.
(3) Shiroishi M., et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100:8856-8861.