Human LIGHT / TNFSF14 Protein, His Tag

Source : 

Human LIGHT, His Tag (LIT-H5247) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1).

 

Molecule : LIGHT

 

Synonyms : CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP 003798.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 20.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.8 kDa. The protein migrates as 23-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS with Arginine, pH7.4

 

Description :

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

 

References :

(1) Mauri DN., et al. 1998, Immunity., 8(1), 21-30.
(2) Granger SW., et al. 2003, Cytokine Growth Factor Rev., 14(3-4), 289-96.
(3) Pasero C., et al. 2009, Curr Mol Med., 9(7), 911-27.