Human LIGHT / TNFSF14 Protein, Fc Tag (active trimer) (MALS verified)

Source : 

Human LIGHT, Fc Tag (active trimer) (MALS verified) (LIT-H5269) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1) trimer Design.

 

Molecule : LIGHT

 

Synonyms : CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP 003798.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 82.6 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 82.6 kDa. The protein migrates as 116 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5

 

Description :

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

 

References :

(1) Mauri DN., et al. 1998, Immunity., 8(1), 21-30.
(2) Granger SW., et al. 2003, Cytokine Growth Factor Rev., 14(3-4), 289-96.
(3) Pasero C., et al. 2009, Curr Mol Med., 9(7), 911-27.