Human LIF R / CD118 Protein, Fc Tag

Source : 

Human LIF R, Fc Tag (LIR-H4252) is expressed from human 293 cells (HEK293). It contains AA Gln 45 - Ser 833 (Accession # P42702-1).

 

Molecule : LIF R

 

Synonyms : LIFR,CD118,FLJ98106,FLJ99923,SJS2,STWS,SWS

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001121143

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 115.5 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 115.5 kDa. The protein migrates as 140-190 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Leukemia inhibitory factor receptor is also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

 

References :

(1) Timmermann, Andreas, et al. 2002, Eur. J. Biochem. (Germany) 269 (11): 2716–26.
(2) Gearing, D.P. et al.,1991, EMBO J. 10 (10): 2839-2848.
(3) Gearing, D.P. et al.,1992, New Biol. 4 (1): 61-65.
(4) Mosley, B. et al.,1996, J. Biol. Chem. 271 (51): 32635-32643.
(5) Lass, A. et al.,2002, Fertil. Steril. 76 (6): 1091-1096.