Human LBP / Lipopolysaccharide Protein, His Tag

Source : 

Human Lipopolysaccharide, His Tag (LBP-H52H5) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Val 481 (Accession # P18428-1 (I465F)).

 

Molecule : Lipopolysaccharide-binding protein / LBP

 

Synonyms : Lipopolysaccharide-binding protein,LBP

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_004130.2 (I465F)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 52.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52.8 kDa. The protein migrates as 62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Lipopolysaccharide-binding protein (LBP),a member of the BPI/LBP/Plunc superfamily, BPI/LBP family, is detected in blood serum. LBP plays a role in the innate immune response. Alao,LBP can bind to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and act as an affinity enhancer for CD14, facilitating its association with LPS. Furthermore, LBP is able to promote the release of cytokines in response to bacterial lipopolysaccharide.

 

References :

(1) Schumann R.R., et al., 1990, Science 249:1429-1431.
(2) Hubacek J.A., et al., 1997, Biochem. Biophys. Res. Commun. 236:427-430.
(3) Eckert J.K., et al., 2013, Immunity 39:647-660.