Human LAP (TGF-beta 1) Protein, His Tag

Source : 

Human LAP (TGF-beta 1), His Tag (LAP-H5245) is expressed from human 293 cells (HEK293). It contains AA Leu 30 - Arg 278 (Accession # NP_000651.3 (C33S)).

 

Molecule : LAP (TGF-beta 1)

 

Synonyms : LAP (TGF-beta 1),LAP (TGFB1),TGFB1,CED,DPD1,LAP,TGF-beta-1,TGFB

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : NP_000651.3 (C33S)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 40 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 40 kDa. The protein migrates as 38-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Transforming growth factor beta 1 ( TGFB1) is also known as TGF-β1, CED, DPD1, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function. TGFB1 is particularly abundant in tissues that make up the skeleton, where it helps regulate bone growth, and in the intricate lattice that forms in the spaces between cells (the extracellular matrix). Within cells, this protein is turned off (inactive) until it receives a chemical signal to become active. TGFB1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGFB1. TGFB1 has been shown to interact with TGF beta receptor 1, LTBP1, YWHAE, EIF3I and Decorin.

 

References :

(1) Ghadami M, et al., 2000, Am. J. Hum. Genet. 66 (1): 143–7.
(2) Assoian R, et al., 1983, J Biol Chem , 258 (11): 7155–60.
(3) Derynck R, et al., 1985, Nature 316 (6030): 701–5.
(4) Letterio J, Roberts A, 1998, Annu Rev Immunol 16: 137–61.