Human LAG-3 / CD223 Protein, Llama IgG2b Fc Tag, low endotoxin

Source : 

Human LAG-3, Llama IgG2b Fc Tag, low endotoxin (LA3-H525c) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Leu 450 (Accession # P18627-1).

 

Molecule : LAG-3

 

Synonyms : LAG3,CD223,FDC

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_002277.4

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 74.0 kDa

 

Characteristics :

This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 74.0 kDa. The protein migrates as 90 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.01 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

 

References :

(1) Triebel F., et al., 1990, J. Exp. Med. 171:1393-1405.
(2) Baixeras E., et al., 1992, J. Exp. Med. 176:327-337.