Human KIR2DL3 / CD158b2 Protein, Fc Tag

Source : 

Human KIR2DL3, Fc Tag (KI3-H5257) is expressed from human 293 cells (HEK293). It contains AA His 22 - His 245 (Accession # NP_056952.2).

 

Molecule : KIR2DL3

 

Synonyms : KIR2DL3,CD158B2,KIRCL23,NKAT2,KIR-023GB,NKAT2a,NKAT2b,NKAT-2,CD158 B2,GL183,KIR-023GB,KIR-K7b,KIR-K7c,KIRCL23,NKAT,p58

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_056952.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 51.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.2 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) is also known as CD158 antigen-like family member B2, KIR-023GB, Killer inhibitory receptor cl 2-3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated transcript 2, p58 natural killer cell receptor clone CL-6, p58.2 MHC class-I-specific NK receptor, CD158b2 and KIR2DL3, which is a single-pass type I membrane protein and belongs to the immunoglobulin superfamily.KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). KIR2DL3 can inhibit the activity of NK cells thus preventing cell lysis.

 

References :

(1) Colonna M., et al., 1995 Science 268:405-408. (2) Doehring C., et al., 1996, Immunogenetics 44:227-230. (3) Maenaka K., et al., 1999, Structure 7:391-398.