Human JAK1 Protein, His Tag

Source : 

Human JAK1, His Tag (JA1-H5547) is expressed from Baculovirus-Insect cells. It contains AA Ala 561 - Asn 852 (Accession # P23458-1).

 

Molecule : JAK1

 

Synonyms : JAK1,JAK-1,JAK1A,JAK1B,Jak1

 

Format : Liquid

 

Category : Enzymes

 

Accession : NP_002218.2

 

Storage : -70℃

 

Shipping condition : Liquid,-70℃Dry ice

 

Molecular Weight : 35.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 35.7 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 500 mM NaCl, 2 mM TCEP, pH8.0

 

Description :

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

 

References :

(1) Anna Usacheva, et al. J Immunol. 2002. 169(3):1302-8.
(2) Sakatsume M, et al. J Biol Chem. 1995. 270(29):17528-34.
(3) Gadina M, et al. Curr Opin Immunol. 2001. 13(3):363-73.