Human Jagged 1 / JAG1 Protein, His Tag

Source : 

Human Jagged 1, His Tag (JA1-H52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 34 - Ser 1046 (Accession # P78504-1).

 

Molecule : Jagged 1

 

Synonyms : CD339,JAG1,Jagged1,hJ1,JAGL1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_000205.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 112.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 112.3 kDa. The protein migrates as 130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).

 

References :

(1) Li L., et al., 1998, Immunity 8:43-55.
(2) Bash J., et al., 1999, EMBO J. 18:2803-2811.
(3) Zimrin A.B., et al., 1996, J. Biol. Chem. 271:32499-32502.