Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W8) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1) (Accession # Q13683-7 (ITGA7X2B) & P05556-1 (ITGB1)).

 

Molecule : Integrin isoform alpha-7X2B beta 1

 

Synonyms : Integrin isoform alpha-7X2B beta 1,ITGA7X2BB1,ITGA7X2B&ITGB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002197.2 (ITGA7X2B) & NP_002202.2 (ITGB1)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 116.5 kDa (ITGA7X2B) & 83.7 kDa (ITGB1)

 

Characteristics :

Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA7X2B and ITGB1, has a calculated MW of 116.5 kDa (ITGA7X2B) and 83.7 kDa (ITGB1). Subunit ITGA7X2B is fused with an acidic tail at the C-terminus and followed by

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.

 

References :

(1) Hodges, BL., et al., 1997, Journal of Cell Science, 110 (22): 2873-2881.
(2) Mielenz, D., et al., 2001, The Journal of Biological Chemistry, 276 (16): 13417-13426.
(3) Samson T., et al., 2004, J. Biol. Chem. 279 (27): 28641-28652.