Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (IT3-H52E3) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3) (Accession # NP_002201.1 (ITGAV) & NP_000203.2 (ITGB3)).

 

Molecule : Integrin alpha V beta 3

 

Synonyms : Integrin alpha V beta 3,ITGAV&ITGB3

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002201.1 (ITGAV) & NP_000203.2 (ITGB3)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 112.9 kDa (ITGAV) & 81.8 kDa (ITGB3)

 

Characteristics :

Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB3, has a calculated MW of 112.9 kDa (ITGAV) and 81.8 kDa (ITGB3). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistid

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

 

References :

(1) Kumar C.S., et al.,1997, J. Biol. Chem. 272:16390-16397.
(2) Bledzka K., et al., 2010, J. Biol. Chem. 285:30370-30374.
(3) Wei Y., et al.,2014, J. Virol. 88:4338-4352.