Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGAV&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52E1) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gln 21 - Asp 728 (ITGB1) (Accession # NP_002201.1 (ITGAV) & NP_002202.2 (ITGB1)).

 

Molecule : Integrin alpha V beta 1

 

Synonyms : Integrin alpha V beta 1,ITGAV&ITGB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002201.1 (ITGAV) & NP_002202.2 (ITGB1)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 112.9 kDa (ITGAV) & 83.7 kDa (ITGB1)

 

Characteristics :

Human ITGAV&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB1, has a calculated MW of 112.9 kDa (ITGAV) and 83.7 kDa (ITGB1). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhisti

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.

 

References :

(1) Balzac F., et al., 1993, J. Cell Biol. 121:17.
(2) Sasaki T., et al., 1998, EMBO J. 17:1606-1613.