Human Integrin alpha E beta 7 (ITGAE&ITGB7) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-H52W7) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Ser 1124 (ITGAE) & Glu 20 - His 723 (ITGB7) (Accession # P38570-1 (ITGAE) & P26010-1 (ITGB7)).

 

Molecule : Integrin alpha E beta 7

 

Synonyms : Integrin alpha E beta 7,ITGAE&ITGB7

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002199.3 (ITGAE) & NP_000880.1 (ITGB7)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 128.6 kDa (ITGAE) & 81.8 kDa (ITGB7)

 

Characteristics :

Human ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAE and ITGB7, has a calculated MW of 128.6 kDa (ITGAE) and 81.8 kDa (ITGB7). Subunit ITGAE is fused with an acidic tail at the C-terminus and followed by a polyhistid

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues. This is a strikingly narrow pattern of expression compared with that of other integrins. Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body.
The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7). This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.

 

References :

(1) Smyth, L., et al., 2007, Clinical and Experimental Immunology., 149(1), 162–170.
(2) Floc’h, A. L.., et al., 2007, Journal of Experimental Medicine., 204(3), 559–570. (3) Manicone, A. M., et al., 2009, The American Journal of Pathology., 175(6), 2319–2331.