Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGA8&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W9) is expressed from human 293 cells (HEK293). It contains AA Phe 39 - Leu 1012 (ITGA8) & Gln 21 - Asp 728 (ITGB1) (Accession # P53708-1 (ITGA8) & P05556-1 (ITGB1)).

 

Molecule : Integrin alpha 8 beta 1

 

Synonyms : Integrin alpha 8 beta 1,ITGA8&ITGB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP 003629.2 (ITGA8) & NP_002202.2 (ITGB1)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 114.6 kDa (ITGA8) & 83.7 kDa (ITGB1)

 

Characteristics :

Human ITGA8&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA8 and ITGB1, has a calculated MW of 114.6 kDa (ITGA8) and 83.7 kDa (ITGB1). Subunit ITGA8 is fused with an acidic tail at the C-terminus and followed by a polyhistid

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Human Integrin alpha 8 beta 1 Heterodimer Protein consists of ITGA8 and ITGB1. The integrin alpha 8 subunit, isolated by low stringency hybridization, is a novel integrin subunit that associates with beta 1. The recently identified alpha 8 integrin subunit associates with beta 1 and is predominantly expressed in smooth muscle and other contractile cells in adult tissues, and in mesenchymal and neural cells during development. In addition, Integrin alpha 8 beta 1 is a receptor for fibronectin and can promote attachment, cell spreading, and neurite outgrowth on fibronectin.

 

References :

(1) Müller U, et al., 1995, Mol Biol Cell 6(4):433-48. (2) Schnapp LM, et al., 1995, J Biol Chem 270(39):23196-202. (3) Marek I, et al., 2014, Cell Adh Migr 8(4): 389–395.