Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-H52W4) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) & Glu 20 - His 723 (ITGB7) (Accession # P13612-1 (ITGA4) & P26010-1 (ITGB7)).

 

Molecule : Integrin alpha 4 beta 7

 

Synonyms : Integrin alpha 4 beta 7,ITGA4&ITGB7

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP 000876.3 (ITGA4) & NP_000880.1 (ITGB7)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 111.4 kDa (ITGA4) & 81.8 kDa (ITGB7)

 

Characteristics :

Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 111.4 kDa (ITGA4) and 81.8 kDa (ITGB7). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed by a polyhistid

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM NaCl, pH7.5

 

Description :

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

 

References :

(1) Arthos Jet, et al., 2008, Nat Immunol., 9(3), 301-9.
(2) Monteiro P, et al., 2011, J Immunol.l., 186(8), 4618-30.
(3) Chen YB, et al., 2013, Bone Marrow Transplant., 48(4), 598-603.