Human Integrin alpha 4 beta 1 (ITGA4&ITGB1) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGA4&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W1) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) & Gln 21 - Asp 728 (ITGB1) (Accession # P13612-1 (ITGA4) & P05556-1 (ITGB1)).

 

Molecule : Integrin alpha 4 beta 1

 

Synonyms : Integrin alpha 4 beta 1,ITGA4&ITGB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP 000876.3 (ITGA4) & NP_002202.2 (ITGB1)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 111.4 kDa (ITGA4) & 83.7 kDa (ITGB1)

 

Characteristics :

Human ITGA4&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB1, has a calculated MW of 111.4 kDa (ITGA4) and 83.7 kDa (ITGB1). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed by a polyhistid

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. Integrin alpha 4 beta 1(Alpha-4/beta-1) is receptors for fibronectin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1.

 

References :

(1) May AE., et al.2000, Blood., 96(2), 506-13.
(2) Luo BH., et al.2007, Annu Rev Immunol., 25, 619-47.
(3) akada, Y., et al. 2007 Genome Biol., 8(5), 215.