Human Integrin alpha 3 beta 1 (ITGA3&ITGB1) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52Wc) is expressed from human 293 cells (HEK293). It contains AA Phe 33 - Glu 991 (ITGA3) & Gln 21 - Asp 728 (ITGB1) (Accession # P26006-2 (ITGA3) & P05556-1 (ITGB1)).

 

Molecule : Integrin alpha 3 beta 1

 

Synonyms : Integrin alpha 3 beta 1,ITGA3&ITGB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002195.1 (ITGA3) & NP_002202.2 (ITGB1)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 113.3 kDa (ITGA3) & 83.7 kDa (ITGB1)

 

Characteristics :

Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA3 and ITGB1, has a calculated MW of 133.3 kDa (ITGA3) and 83.7 kDa (ITGB1). Subunit ITGA3 is fused with an acidic tail at the C-terminus and followed by a polyhistid

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

 

References :

(1) Fukushi J, et al. 2004. Mol Biol Cell. 15(8):3580-90.
(2) Mueller SC, et al. 1999. J Biol Chem. 274(35):24947-52.