Human Integrin alpha 11 beta 1 (ITGA11&ITGB1) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGA11&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 23 - Pro 1141 (ITGA11) & Gln 21-Asp 728 (ITGB1) (Accession # Q9UKX5-1 (L524R) (ITGA11) & P05556-1 (ITGB1)).

 

Molecule : Integrin alpha 11 beta 1

 

Synonyms : Integrin alpha 11 beta 1,ITGA11&ITGB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001004439.1 (L524R) (ITGA11) & NP_002202.2 (ITGB1)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 131.6 kDa (ITGA11) & 82.7 kDa (ITGB1)

 

Characteristics :

Human ITGA11&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA11 and ITGB1, has a calculated MW of 131.6 kDa (ITGA11) and 82.7 kDa (ITGB1). Subunit ITGA11 is fused with an acidic tail at the C-terminus and followed by a polyhi

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrin alpha 11 beta 1 is a receptor for collagen. The alpha11 cDNA encodes a mature protein with a large 1120-residue extracellular domain that contains an I-domain of 207 residues and is linked by a transmembrane domain to a short cytoplasmic domain of 24 amino acids. The deduced alpha11 protein shows the typical structural features of integrin alpha-subunits and is similar to a distinct group of alpha-subunits from collagen-binding integrins.

 

References :

(1) Velling T., et al.,2002, J Biol Chem., 277(40), 37377-81.
(2) Lehnert K., et al.,1999,Genomics., 260(2), 179-87.
(3) Luo BH., et al., 2007,Annu Rev Immunol., 25, 619-47.