Human Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52Wa) is expressed from human 293 cells (HEK293). It contains AA Phe 23 - Ser 1122 (ITGA10) & Gln 21 - Asp 728 (ITGB1) (Accession # O75578-1 (ITGA10) & P05556-1 (ITGB1)).

 

Molecule : Integrin alpha 10 beta 1

 

Synonyms : Integrin alpha 10 beta 1,ITGA10&ITGB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_003628.2 (ITGA10) & NP_002202.2 (ITGB1)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 126.6 kDa (ITGA10) & 83.7 kDa (ITGB1)

 

Characteristics :

Human ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA10 and ITGB1, has a calculated MW of 126.6 kDa (ITGA10) and 83.7 kDa (ITGB1). Subunit ITGA10 is fused with an acidic tail at the C-terminus and followed by a polyhi

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Human integrin alpha(10)I domain as a recombinant protein to reveal its ligand binding specificity. In general, alpha(10)I did recognize collagen types I-VI and laminin-1 in a Mg(2+)-dependent manner, whereas its binding to tenascin was only slightly better than to albumin. Alpha 10 beta 1 is a known collagen-binding I domain integrin, in addition to α1β1, α2β1 and α11β1. GROGER found in the N-terminal domain of collagens I and III, is only weakly recognised by α10β1, an important collagen receptor on chondrocytes, contrasting with the other collagen-binding integrins.

 

References :

(1) Gullberg DE, et al. Prog Histochem Cytochem. 2002. 37(1):3-54.
(2) Tulla M, et al. J Biol Chem. 2001. 276(51):48206-12.
(3) Hamaia SW, et al. Matrix Biol. 2017. 59:80-94.