Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein, His Tag&Tag Free

Source : 

Human ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52Wb) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Pro 1141 (ITGA1) & Gln 21 - Asp 728 (ITGB1) (Accession # P56199-1 (ITGA1) & P05556-1 (ITGB1)).

 

Molecule : Integrin alpha 1 beta 1

 

Synonyms : Integrin alpha 1 beta 1,ITGA1&ITGB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_852478.1 (ITGA1) & NP_002202.2 (ITGB1)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 130.0 kDa (ITGA1) & 83.7 kDa (ITGB1)

 

Characteristics :

Human ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA1 and ITGB1, has a calculated MW of 130.0 kDa (ITGA1) and 83.7 kDa (ITGB1). Subunit ITGA1 is fused with an acidic tail at the C-terminus and followed by a polyhistid

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. The Integrin alpha-1/beta-1 and Integrin alpha-2/beta-1 integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

 

References :

(1) Senger DR, et al. 2002. Am J Pathol. 160(1):195-204.
(2) Mattila E, et al. 2005. Nat Cell Biol. 7(1):78-85.