Human IL-7 R alpha / CD127 Protein, Fc Tag

Source : 

Human IL-7 R alpha, Fc Tag (ILA-H5258) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Gly 236 (Accession # P16871-1).

 

Molecule : IL-7 R alpha

 

Synonyms : IL7Ra,CD127

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002176

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 51.0 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.0 kDa. The protein migrates as 66-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra /CD127 contains 1 fibronectin type-III domain. IL7Ra /CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra /CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

 

References :

(1) Noguchi M., et al., 1994, Science 262 (5141): 1877–80.
(2) Kroemer RT., et al., 1997, Protein Eng. 9 (12): 1135–42.
(3) McElroy C.A., et al., 2009, Structure 17:54-65.