Human IL-5 R alpha / CD125 Protein, Fc Tag

Source : 

Human IL-5 R alpha, Fc Tag (ILA-H5259) is expressed from human 293 cells (HEK293). It contains AA Asp 21 - Trp 342 (Accession # Q01344-1).

 

Molecule : IL-5 R alpha

 

Synonyms : IL5Ra,CD125

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_000555.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 63.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.2 kDa. The protein migrates as 70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.

 

References :

(1) Tavernier J., ET AL., 1991, Cell 66:1175-1184.
(2) Patino E., et al., 2011, Structure 19:1864-1875.